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American Journal of Epidemiology Vol. 120, No. 4: 643-648
Copyright © 1984 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
EFFEC OF THE USE OF UNRELIABLE SURROGATE VARIABLES ON THE VALIDITY OF EPIDEMIOLOGIC RESEARCH STUDIES
1Department of Biostatiatica, School of Public Health, University of North Carolina Chapel Hill, NC 27514
Reprint requests to Dr. Kupper
When certain key factors of interest in epidemiologic research studies cannot be measured directly, epidemiologists often turn to the use of surrogate vailables. The potential bias in making statistical Inferences about an adjusted exposure-disease association parameter (e.g., a partial correlation) is described as a function of the degree of unreliability In the surrogate variables used in place of the underlying disease, exposure, and confounding factors of real interest, it Is shown that unreliability in the surrogate confounder is much more apt to produce seriously misleading Inferences than is unreliability in the surrogate measures for disease and exposure. Practical methods are discussed for dealing with less than perfectly reliable surrogate variables.
biometry; epidemiologic methods
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