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American Journal of Epidemiology Vol. 120, No. 4: 559-564
Copyright © 1984 by The Johns Hopkins University School of Hygiene and Public Health

research-article

INVESTIGATION OF A CLUSTER OF ANENCEPHALY AND SPINA BIFIDA

CHARLES D. HEAREY1,, JOHN A. HARRIS2, MARC S. USATIN3, DAVID M. EPSTEIN2, HANS K. URY4 and RAYMOND R. NEUTRA2

1Department of Pediatrics, Kaiser-Permanente Medical Center 200 Muir Rd., Martinez, CA 94553
2Departments Defects Monitoring Program, Epidemiological Studies Section, California State Department of Health Services Berkeley, CA
3Department of Pediatrics, Kaiser-Permanente Medical Center Walnut Creek, CA
4Division of Statistics, University of California Davis, CA

Reprint requests to Dr. Hearey

Environmental factors remain undefined as possible causes of spins bifida and anencephaly. The authors noted a fivefold increased incidence for 1979–1980 in the Antioch-Pittsburg, California area, prompting a case-control study. They studied nine case and 27 control mothers as well as eight case and 17 control fathers to evaluate factors Including residence, occupation, drug use, Illnesses, and pesticide or chemical exposure. Except for fathers' smoking (p<0.05), no exposure was associated with neural tube defects.

anencephaly; environmental exposure; neural tube defects; spins bifida; smoking; toxicology


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