American Journal of Epidemiology Vol. 120, No. 3: 342-349
Copyright © 1984 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
ASSOCIATION BETWEEN SERUM SELENIUM AND THE RISK OF CANCER
1Research Institute of Public Health and Department of Community Health. University of Kuopio Kuopio, Finland
2National Public Health Institute Helsinki. Finland
Reprint requests to Dr. Jukka T. Salonen, Department of Community Health, University of Kuopio, Box 6, 70211 Kuopio 1, Finland
A matched-pair analysis was conducted with data based on a prospective six-year follow-up of a random population sample to study the association between serum selenium and the risk of cancer. Case-control pairs were from a population, after exclusions, of 8,113 persons examined in 1972 from two counties in eastern Finland. Cases were 31- to 59-year-old men and women initially free of cancer. One control was matched to each case according to age, gender, daily tobacco consumption, and serum cholesterol concentratlon. The mean serum selenium of the 128 cases was 50.5 µg/llter and that of the controls was 54.3 µg/llter (p = 0.012 tor dtfference). When the residual variation in tobacco consumptlon and serum cholesterol as well as that in four other possible confounders was allowed for in a multiple logistic model, serum selenium of less than 45 µg/llter was associated with a relatlve rlsk of cancer of 3.1 (95% confidence interval, 1.5–6.7, p < 0.01). These data support the hypothesis that selenium deficiency increases the rlsk of certain cancers in middle-aged persons.
epidemlologlc methods; longltudlnal studles; neoplasms; selenium; trace elements
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. R. Marshall, W. Sakr, D. Wood, D. Berry, C. Tangen, F. Parker, I. Thompson, S. M. Lippman, R. Lieberman, D. Alberts, et al. Design and Progress of a Trial of Selenium to Prevent Prostate Cancer among Men with High-Grade Prostatic Intraepithelial Neoplasia. Cancer Epidemiol. Biomarkers Prev., August 1, 2006; 15(8): 1479 - 1484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Connelly-Frost, C. Poole, J. A. Satia, L. L. Kupper, R. C. Millikan, and R. S. Sandler Selenium, apoptosis, and colorectal adenomas. Cancer Epidemiol. Biomarkers Prev., March 1, 2006; 15(3): 486 - 493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhuo, A. H. Smith, and C. Steinmaus Selenium and Lung Cancer: A Quantitative Analysis of Heterogeneity in the Current Epidemiological Literature Cancer Epidemiol. Biomarkers Prev., May 1, 2004; 13(5): 771 - 778. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Jackson, C. S. Broome, and F. MCArdle Marginal Dietary Selenium Intakes in the UK: Are There Functional Consequences? J. Nutr., May 1, 2003; 133(5): 1557S - 1559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Reid, A. J. Duffield-Lillico, L. Garland, B. W. Turnbull, L. C. Clark, and J. R. Marshall Selenium Supplementation and Lung Cancer Incidence: An Update of the Nutritional Prevention of Cancer Trial Cancer Epidemiol. Biomarkers Prev., November 1, 2002; 11(11): 1285 - 1291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. A. Zeegers, R. A. Goldbohm, P. Bode, and Piet. A. van den Brandt Prediagnostic Toenail Selenium and Risk of Bladder Cancer Cancer Epidemiol. Biomarkers Prev., November 1, 2002; 11(11): 1292 - 1297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Duffield-Lillico, M. E. Reid, B. W. Turnbull, G. F. Combs Jr., E. H. Slate, L. A. Fischbach, J. R. Marshall, and L. C. Clark Baseline Characteristics and the Effect of Selenium Supplementation on Cancer Incidence in a Randomized Clinical Trial: A Summary Report of the Nutritional Prevention of Cancer Trial Cancer Epidemiol. Biomarkers Prev., July 1, 2002; 11(7): 630 - 639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Rao, B. Puschner, and T. A. Prolla Gene Expression Profiling of Low Selenium Status in the Mouse Intestine: Transcriptional Activation of Genes Linked to DNA Damage, Cell Cycle Control and Oxidative Stress J. Nutr., December 1, 2001; 131(12): 3175 - 3181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cases, V. Vacchina, A. Napolitano, B. Caporiccio, P. Besancon, R. Lobinski, and J.-M. Rouanet Selenium from Selenium-Rich Spirulina Is Less Bioavailable than Selenium from Sodium Selenite and Selenomethionine in Selenium-Deficient Rats J. Nutr., September 1, 2001; 131(9): 2343 - 2350. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. D. Mark, Y.-L. Qiao, S. M. Dawsey, Y.-P. Wu, H. Katki, E. W. Gunter, J. F. Fraumeni Jr., W. J. Blot, Z.-W. Dong, and P. R. Taylor Prospective Study of Serum Selenium Levels and Incident Esophageal and Gastric Cancers J Natl Cancer Inst, November 1, 2000; 92(21): 1753 - 1763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Y. Nomura, J. Lee, G. N. Stemmermann, and G. F. Combs Jr. Serum Selenium and Subsequent Risk of Prostate Cancer Cancer Epidemiol. Biomarkers Prev., September 1, 2000; 9(9): 883 - 887. [Abstract] [Full Text]
|
|
|
|
|
|
C. Ip Lessons from Basic Research in Selenium and Cancer Prevention J. Nutr., November 1, 1998; 128(11): 1845 - 1854. [Abstract] [Full Text]
|
|