Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (22)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by ASELTON, P.
Right arrow Articles by ROTHMAN, K. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by ASELTON, P.
Right arrow Articles by ROTHMAN, K. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Vol. 120, No. 2: 251-256
Copyright © 1984 by The Johns Hopkins University School of Hygiene and Public Health

research-article

PYLORIC STENOSIS AND MATERNAL BENDECTIN EXPOSURE

PAMELA ASELTON1, HERSHEL JICK1,, STEPHEN J. CHENTOW2, DAVID R. PERERA2, JUDITH R. HUNTER2 and KENNETH J. ROTHMAN3

1Boston Collaborative Drug Surveillance Program, Boston University Medical Center Waltham, MA
2Group Health Cooperative of Puget Sound Seattle, WA
3Department of Epidemiology, Harvard School of Public Health Boston, MA

Reprint requests to Dr. Hershel Jick, Boston Collaborative Drug Surveillance Program, 400-1 Totten Pond Road, Waltham, MA 02154

As part of a long-term follow-up of structural disorders present at birth or shortly thereafter in infants born at Group Health Cooperative of Puget Sound, all infants with a diagnosis of pyloric stenosis born between July 1, 1977 and June 30, 1982, were identified. Automated pharmacy profiles were examined to determine whether an association between maternal Bendectin use in the first trimester and infantile hypertrophic pyloric stenosis existed. Among the 3,835 women exposed to Bendectin while pregnant, in this group of 13,346 births, 13 had infants who developed pyloric stenosis, and among the 9,511 women not exposed, 13 had infants who developed pyloric stenosis, resulting in a risk ratio estimate of 2.5 (95% confidence interval (CI) 1.2–5.2). When mothers were divided according to the number of prescriptions for Bendectin filled, the relative risk estimate increased from 1.2 (95% CI 0.4–4.4) in women who filled only one prescription to 7.6 (95% CI 4.9–11.6) in women who filled five or more prescriptions for Bendectin during their pregnancy.

abnormalities, drug-induced; pyloric stenosis; pregnancy


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Arch Pediatr Adolesc MedHome page
L. E. Mitchell and N. Risch
The Genetics of Infantile Hypertrophic Pyloric Stenosis: A Reanalysis
Arch Pediatr Adolesc Med, November 1, 1993; 147(11): 1203 - 1211.
[Abstract] [PDF]

Home page
 Arch Pediatr Adolesc MedHome page
M. B. Jedd, L. J. Melton III, M. R. Griffin, B. Kaufman, A. D. Hoffman, D. Broughton, and P. C. O'Brien
Factors Associated With Infantile Hypertrophic Pyloric Stenosis
Arch Pediatr Adolesc Med, March 1, 1988; 142(3): 334 - 337.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.