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American Journal of Epidemiology Vol. 119, No. 6: 944-958
Copyright © 1984 by The Johns Hopkins University School of Hygiene and Public Health

other

THE COLLABORATIVE LIPID RESEARCH CLINICS PROGRAM FAMILY STUDY: II. RESPONSE RATES, REPRESENTATIVENESS OF THE SAMPLE, AND STABILITY OF LIPID AND LIPOPROTEIN LEVELS

KADAMBARI K. NAMBOODIRI1, PHILIP P. GREEN1, CAROLYN WALDEN2, ELLEN B. KAPLAN1, DEBORAH DAWSON1, KATHE KELLY3, MAREK MACIOLOWSKI1, JOHN A. MORRISON4, ROBERT C. ELSTON5, MELISSA AUSTIN6, BASIL M. RIFKIND3, and RATNA THOMAS1

1Department of Biostatistics, University of North Carolina Chapel Hill, NC
2Department of Biostatistics, University of Washington Seattle, WA
3Lipid Metabolism-Atherogenesis Branch, NHLBI, National Institutes of Health Federal Bldg., Rm. 401, Bethesda, MD 20205.
4Cincinnati Clinical Research Center, Cincinnati General Hospital Cincinnati, OH
5Department of Biometry, Louisiana State University Medical Center New Orleans, LA
6Department of Community Medicine, University of California San Diego, La Jolla, CA

(Reprint requests to Dr. Basil M. Rifkind.)

Namboodirl, K. K., P. P. Green, C. Walden, E. B. Kaplan, D. Dawson, K, Keliy, M. Maciolowskl, J. A. Morrison, R. C. Elaton, M. Austin, B. M. Rhfkind (NHLBi, NiH, Bethesda, MD 20205) and R. Thomas. The Collaborative Lipid Research Clinics Program Family Study. ii. Response rates, representativeness of the sample, and stability of lipld and llpoproteln levels. Am J Epidemiol 1984; 119: 944-58.

The Collaborative Family Study (1975–1978), the third phase of the Lipld Research Clinics Program Population Studies, covers 2405 probands and 15, 693 of their relatives from nine North American communities. This sample was examined for participation differences across race, sex, locality, educational level, and reason for selection. The participation rates were somewhat lower for blacks, younger age groups, and subjects with lower educational levels. The probands' reason for selection into the study had little impact on the participation of probands or relatives. Moreover, based on information gathered at earlier examinations on eligible Family Study probands, the coronary risk factor profile appeared to be similar among participants and nonpar-tlclpants. The available longitudinal lipld data on probands indicated general consistency in lipld levels within subjects over short periods of time, in cholesterol even more so than in triglycerides. Among age strata, the younger subjects showed the least intrapersonal stability, especially for triglycerides.

data collection; family characteristics; liplds; lipoprotelns


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