American Journal of Epidemiology Vol. 119, No. 5: 742-750
Copyright © 1984 by The Johns Hopkins University School of Hygiene and Public Health
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PARENTAL SURVIVAL, AN INDEPENDENT PREDICTOR OF LONGEVITY IN MIDDLE-AGED PERSONS
1Department of Epidemiology, Erasmus University Rotterdam P. 0. Box 1738, 3000 DR Rotterdam, The Netherlands.
2Department of Epidemiology, Netherlands Heart Foundation The Hague.
3 Amsterdam
4Wilhelmina Gasthuis, University of Amsterdam
(Reprint requests to Dr. Jan P. Vandenbroucke.)
Vandenbroucke, J. P. (Dept. of Epidemiology, Erasmus U. Rotterdam, The Netherlands), A. W. Matroos, C. van der Heide-Wessel and R. M. van der Heide. Parental survival, an independent predictor of longevity in middle-aged persons. Am J Epidemiol 1984; 119: 742–50.
In a 25-year follow-up of 2370 middle-aged civil servants and spouses of civil servants, the authors studied the effect of the number of parents (none, one, or both) which a middle-aged person still has alive on this person's survival. Among men, no relationship was found with the number of parents alive after 15 years of follow-up and a weak gradient was found after 25 years. Among women, there was a clear gradient of mortality according to the number of parents alive, both after 15 and after 25 years. In a logistic regression analysis of mortality, after 25 years, the age-adjusted effect of having both parents alive relative to none was significant in men and women (for men: odds ratio = 0.63, 95% confidence interval = 0.42–0.97; for women: odds ratio = 0.36, 95% confidence interval = 0.19–0.69). These estimates did not change materially upon inclusion of other determinants for chronic disease and death into the model (smoking, blood pressure, serum cholesterol, and body mass index). The authors concluded that the parental effect was independent of these risk factors.
family; genetics; longevity; survival
(Present address, Hoechst Holland N. V., Amsterdam.)
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