Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (11)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by WILLIAMS, P. L.
Right arrow Articles by STEVENS, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by WILLIAMS, P. L.
Right arrow Articles by STEVENS, D. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Vol. 119, No. 4: 591-602
Copyright © 1984 by The Johns Hopkins University School of Hygiene and Public Health

other

IMMUNOLOGIC RESPONSIVENESS AND SAFETY ASSOCIATED WITH THE COCCIDIOIDES IMMITIS SPHERULE VACCINE IN VOLUNTEERS OF WHITE, BLACK, AND FILIPINO ANCESTRY

PAUL L. WILLIAMS1,2,3, DAVID L. SABLE1, STEVEN P. SORGEN4, DEMOSTHENES PAPPAGIANIS5, H. B. LEVINE6, STEPHANIE K. BRODINE7, BYRON W. BROWN8, F. CARL GRUMET9 and DAVID A. STEVENS2,3,10

1Department of internal Medicine, Naval Hospital Lemoore, CA
2Division of Infectious Diseases, Santa Clara Valley Medical Center, and Institute for Medical Research San Jose, CA
3Division of Infectious Diseases, Department of Medicine, Stanford University School of Medicine Stanford, CA
4Department of Preventive Medicine, Naval Hospital Lemoore, CA
5Department of Medical Microbiology, University of California Medical School Davis, CA
6Naval Biosciences Laboratory, School of Public Health, University of California Berkeley, CA
7Naval Dispensary Treasure Island, CA Naval Regional Medical Center Oakland, CA
8Division of Biostatistics, Department of Family, Community, and Preventive Medicine, Stanford University School of Medicine Stanford, CA
9Department of Pathology, Stanford University School of Medicine Stanford, CA

10Reprint requests to Dr. D. A. Stevens, Department of Medicine, Santa Clara Valley Medical Center, 751 S. Bascom Ave., San Jose, CA 95128.

A trial of the killed Coccidioides immitis spherule vaccine was undertaken with 151 healthy skin test negative adult volunteers and controls to evaluate the safety of selected regimens, the induction of humoral and cell-mediated immune responses, and to determine if there were immunogenetic differences in these responses. The vaccine was given as three intra-deltoid doses over 8 weeks. No severe systemic symptoms were noted, although 3% of 3.5 mg doses (but no 1.75 mg doses) were associated with severe local reactions. Half the vaccinees had skin test conversions, which generally persisted ≥6 months, two-thirds showed boosting of lymphocyte transformation in vitro, and 16% given three 3.5 mg doses developed antibody. There was an association between degree of local adverse vaccine reaction and immunostimulation, and a trend to immune response in persons of O blood type and with some HLA phenotypes. There was no evidence of deficient response to vaccination in subpopulatlons known to respond to coccidioidal infection poorly. A regimen of three 1.75 mg doses appears to be safe and without reduced Immunogenicity, and there is no evidence dosage modification for certain subpopulatlons would be necessary in efficacy studies.

antigens, fungal; coccidioides; coccidioidomycosis; fungal vaccines; immunogenetics; mycology; vaccines


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Clin. Microbiol. Rev.Home page
R. A. Cox and D. M. Magee
Coccidioidomycosis: Host Response and Vaccine Development
Clin. Microbiol. Rev., October 1, 2004; 17(4): 804 - 839.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.