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American Journal of Epidemiology Vol. 119, No. 2: 250-260
Copyright © 1984 by The Johns Hopkins University School of Hygiene and Public Health

other

EPIDEMIOLOGIC INVESTIGATION OF AN OIL-ASSOCIATED PNEUMONIC PARALYTIC EOSINOPHILIC SYNDROME IN SPAIN

JOSÉ G. RIGAU-PÉREZ1, LUIS PÉREZ-ALVAREZ2, SEGUNDO DUENAS-CASTRO3, KEEWHAN CHOI1, STEPHEN B. THACKER1, JOSÉL. GERMAIN4, GERMÁN GONZÁLEZ-DE-ANDRÉS5, LUIS CANADA-ROYO6 and FLORENCIO PÉREZ-GALLARDO7

1Epidemiology Program Office, Centers for Disease Control Atlanta, GA 30333. (Reprint requests to Dr. Rigau-Pérez at this address.)
2Department of Preventive Medicine and Public Health, La Paz Social Security Hospital Madrid, Spain
3The Social and Preventive Medicine Department, Universidad Autónoma de Madrid Madrid, Spain
4Provincial Health Office Ávila, Spain
5Municipal Health Office Las Navas del Marques, Spain
6Health Programs Bureau, Ministry of Health and Consumer Affairs Madrid, Spain
7National Center for Microbiology, Virology and immunology, Ministry of Health and Consumer Affairs Madrid, Spain

Rlgau-Pérez, J. G. (Epidemiology Program Office, CDC, Atlanta, GA 30333), L. Pérez-Alvarez, S. Duenas-Castro, K. Choi, S. B. Thacker, J. L. Germain, G. González-de-Andrés, L. Canada-Royo and F. Pérez-Gallardo. Epidemiologic investigation of an oll-assoclated pneumonic paralytic eoslnophlllc syndrome in Spain. Am J Epidemiol 1984; 119: 250–60.

From May 1 to December 26, 1961, a previously undescribed illness caused 277 deaths and the hospitalizatlon of 12, 656 persons in Spain. The disease was characterized by pneumonltls, eoslnophllia, and marked loss of muscle mass and function. A succession of case-control studies was done in the town of Las Navas del Marqués (province of Avila) located 47 miles northeast of Madrid and with a population of 4009 people. The studies confirmed the association between illness and consumption of an illegally sold cooking oil. Other risk factors identified in the linear logistic regression analysis included involvement in various kitchen activities, increased average time spent inside the house, and the purchase of cooking oil from a specific street vendor. Although the oil was found to be a mixture of vegetable and animal fats contaminated with aniline and anillde-oll complexes, the specific etlologlc mechanism of the disease has not been determined.

Brassica; eosinophllia; food contamination; oils; paralysis; pneumonia


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 Hum Exp ToxicolHome page
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Human and Experimental Toxicology, May 1, 1985; 4(3): 231 - 235.
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