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American Journal of Epidemiology Vol. 119, No. 2: 159-166
Copyright © 1984 by The Johns Hopkins University School of Hygiene and Public Health


other

GLYCOSYLATED HEMOGLOBIN DETERMINATION FROM CAPILLARY BLOOD SAMPLES

UTILITY IN AN EPIDEMIOLOGIC SURVEY OF DIABETES

ROBERT E. FERRELL1,, CRAIG L. HANIS1, LYDIA AGUILAR1, BRIAN TULLOCH2, CHARLES GARCIA2 and WILLIAM J. SCHULL1

1Center for Demographic and Population Genetics, Graduate School of Biomedical Sciences and School of Public Health, The University of Texas Health Science Center Houston, TX
2Medical School, The University of Texas Health Science Center Houston, TX

Reprint requests to Dr. Ferrell, Center for Demographic and Population Genetics, Graduate School of Biomedical Sciences, The University of Texas Health Science Center, P.O. Box 20334, Houston, TX 77225.

Ferrell, R. E. (Graduate School of Biomedlcal Sciences, P.O. Box 20334, Houston, TX 77225), C. L. Hanis, L. Agullar, B. Tulloch, C. Garcia and W. J. Schull. Glycosylated hemoglobin determination from capillary blood samples: utility in an epldemlologlc survey of diabetes. Am J Epidemiol 1984; 119: 159–66.

Total glycosylated hemoglobin was measured from capillary blood specimens obtained from a sample of 1880 individuals of Mexican-American ancestry residing in Starr County, Texas, between January 1981 and February 1982, as part of an epidemiologic survey to assess the prevalence of non-insulln-dependent diabetes mellltus (Type ii). No significant difference was found between males and females. Diabetics were found to have significantly higher levels of glycosylated hemoglobin than nondiabetics. However, among diabetics, there was no significant difference between newly diagnosed and known diabetics, and known diabetics taking medication did not differ significantly from those not taking medication. An analysis of the specificity and sensitivity of glycosylated hemoglobin, fasting blood glucose, and casual blood glucose determinations as screening devices in a survey of diabetes prevalence reveals that glycosylated hemoglobin is superior to casual blood glucose determination. The conditions under which various screening devices might be more effective are discussed.

diabetes mellitus; epidemiologic methods; hemoglobin A, glycosylated; Hispanic Americans


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