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American Journal of Epidemiology Vol. 118, No. 4: 592-598
Copyright © 1983 by The Johns Hopkins University School of Hygiene and Public Health

other

A REFORMULATION OF THE SERIALLY ADDITIVE EXPECTED DOSE METHOD FOR OCCUPATIONAL COHORT DATA

JAY H. LUBIN

Lubin, J. H. (Environmental Epidemiology Branch, NCI, Bethesda, MD 20205). A reformulation of the serially additive expected dose method for occupational cohort data. Am J Epidemiol 1983; 118: 592–8.

The serially additive expected dose method for the analysis of occupational cohort data can be biased whenever worker exposure is associated with length of follow-up. An Illustration shows that this bias can act to either enhance or reduce the degree of association between disease and exposure. The serially additive expected dose method can be modified, then embedded In a classical Cox proportional hazards model context to eliminate the analytic bias. A chisquare test of no exposure association is derived.

epidemiologic methods; occupational diseases; prospective studies; retrospective studies; statistics


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