American Journal of Epidemiology Vol. 118, No. 3: 301-312
Copyright © 1983 by The Johns Hopkins University School of Hygiene and Public Health
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RECURRENT URBAN HISTOPLASMOSIS, INDIANAPOLIS, INDIANA, 1980–1981
1Bacterial Diseases Division, Center for Infectious Diseases, Centers for Disease Control Atlanta, GA 30333
3Department of Medicine, Indiana University Medical Center Indianapolis, IN
4Department of Pathology, Indiana University Medical Center Indianapolis, IN
5Division of Mycotic Diseases, Center for Infectious Diseases, Centers for Disease Control Atlanta, GA
6Division of Public Health, Health and Hospital Corporation of Marion County Indianapolis, IN
Reprint requests to Dr. Schlech at this address
Schlech, W. F., Ill (CDC, Atlanta, GA 30333), L. J. Wheat, J. L. Ho, M. L. V. French, R. J. Weeks, R. B. Kohler, C. E. Deane, H. E. Eitzen, and J. D. Band. Recurrent urban histoplasmosis, Indianapolis, Indiana, 1980–1981. Am J Epidemiol 1983; 118: 301–12.
In January 1981, informal surveillance of acute histoplasmosis in Indianapolis, Indiana, revealed a marked increase in disease activity for the last quarter of 1980. Fifty-one patients with onset of acute histoplasmosis during this period were identified through review of hospital admissions, emergency room visits, and serologic records at Indianapolis hospitals and the Indiana State Board of Health. In a retrospective case-control study, the authors found a significant association between developing acute histoplasmosis during this period and working or attending classes in a 2 sq mi (5.2 sq km) area encompassing the Indiana University-Purdue University campus (p = 0.015, Fisher's exact test). A review of construction activities on or near the campus during the epidemic period suggested that the probable source of infection was excavation activity for a large new indoor swimming complex (natatorium). Skin tests and serosurveys of students on campus by a newly developed radioim-munoassay for histoplasmal immunoglobulin M antibodies supported the association of infection with exposure to this site (p < 0.05).
epidemics; histoplasmosis
2Present address: Departments of Medicine and Microbiology, Dalhousie University Faculty of Medicine, Halifax, Nova Scotia, Canada.
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