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American Journal of Epidemiology Vol. 117, No. 5: 559-565
Copyright © 1983 by The Johns Hopkins University School of Hygiene and Public Health


research-article

IMPACT OF RECENT CHANGES IN DIAGNOSTIC CRITERIA ON THE APPARENT NATURAL HISTORY OF DIABETES MELLITUS

L. JOSEPH MELTON, III1, PASQUALE J. PALUMBO2, MARK S. DWYER3 and CHU-PIN CHU1

1Department of Medical Statistics and Epidemiology, Mayo Clinic Rochester, MN 55905. (Reprint requests to Dr. Melton.)
2Division of Endocrinology, Department of Internal Medicine Mayo Clinic
3Mayo Medical School Rochester, MN

The effect of changing from the original to the new National Diabetes Data Group diagnostic criteria for diabetes mellitus was to delete 16.5% of the original diabetes incidence cohort described among Rochester, Minnesota, residents In 1945–1969, to shift the clinical spectrum at diagnosis toward more severe disease, to reduce relative survival, and to increase the risk of developing macro- or microvascular complications. The changes in apparent natural history were unexpectedly modest in magnitude, however, and should have little practical effect on comparisons of diabetes prognosis under the two different sets of diagnostic criteria.

classification; diabetes mellitus; diagnosis; prognosis


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