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American Journal of Epidemiology Vol. 116, No. 6: 1022-1032
Copyright © 1982 by The Johns Hopkins University School of Hygiene and Public Health

research-article

ASSOCIATION ARRAYS FOR COMPARING FAMILIAL TOTAL CHOLESTEROL, HIGH DENSITY LIPOPROTEIN CHOLESTEROL, AND TRIGLYCERIDE SIMILARITY IN THE ISRAELI POPULATION BY COUNTRY OF ORIGIN

SAMUEL KARLIN1,, DORTT CARMELLI2, YECHIEL FRIEDLANDER3, PAUL T. WILLIAMS1, TIRZA COHEN3 and YECHIZKEL STEIN3

1Dept of Mathematics, Stanford U. , Stanford CA 94305
2SRI International Menlo Park, CA
3Dept of Medicine B, Hadassa Hospital Jerusalem, Israel

reprint requests to Dr. Karlin at this address

The method of association arrays Is applied to plasma total cholesterol, triglyceride, and high density lipoprotein cholesterol concentrations measured for 2485 young men and women aged 17–18 years and living In Jerusalem, and for their parents. These triad families are divided Into five groups according to whether both parents were born In Asia, North Africa, Europe-America, or Israel, or whether they were of mixed "origins." Stronger associations are present for all lipid and lipoprotein cholesterol variables in Asian and African families relative to families of other origins, possibly reflecting the more disciplined life-style patterns In these families relative to other families. Parent and offspring values exhibit positive association for all lipid variables In all groups. Patterns of familial similarity revealed by the association arrays are discussed In relation to historic and cultural differences among groups.

cholesterol; lipoproteins, HDL; triglycerides


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