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American Journal of Epidemiology Vol. 114, No. 4: 548-553
Copyright © 1981 by The Johns Hopkins University School of Hygiene and Public Health

research-article

SPONTANEOUS ABORTION OVER TIME: COMPARING OCCURRENCE IN TWO COHORTS OF WOMEN A GENERATION APART

ALLEN J. WILCOX1,, ALAN E. TRELOAR2 and DALE P. SANDLER1

1Biometry Branch, Epidemiology Program, National Institute of Environmental Health Sciences Research Triangle Park, NC 27709
2Carolina Population Center and the Department of Obstetrics and Gynecology, University of North Carolina Chapel Hill, NC

Reprint requests to Dr. Wilcox.

A prospective study of menstrual cycles and reproductive outcomes has been in progress since 1935. Data from this study are used to describe the risk of spontaneous abortion in two time periods 26 years apart Out of the total of 3889 women who have enrolled in this study, two cohorts of women are selected for analysis: cohort one consists of 2070 university students who entered the study in 1935–1944, and cohort two consists of 1375 students a generation later, 1961–1970. Cohort one has contributed 2408 pregnancies, and cohort two, 1493 pregnancies. Overall spontaneous abortion risk for the two cohorts is 16.9% and 13.1%, respectively. However age-specific risks of spontaneous abortion do not differ for the two groups, nor is there a difference in the gestational duration of spontaneously aborted pregnancies.

abortion (miscarriage); prospective studies


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