Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by MORENS, D. M.
Right arrow Articles by NELSON, D. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MORENS, D. M.
Right arrow Articles by NELSON, D. B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Vol. 114, No. 3: 406-416
Copyright © 1981 by The Johns Hopkins University School of Hygiene and Public Health

research-article

SURVEILLANCE OF REYE SYNDROME IN THE UNITED STATES, 1977

DAVID M. MORENS1,, JOHN Z. SULLIVAN-BOLYAI1, JAY E. SLATER2, LAWRENCE B. SCHONBERGER1 and DAVID B. NELSON1

1Viral Diseases Division, Center for Infectious Diseases Centers for Disease Control, Atlanta, GA 30333
2Harvard Medical School Boston, MA

Address for reprints: David M. Morens, M.D., Building 7, Room SB 16, Centers for Disease Control, Atlanta, GA 30333

Between December 1, 1976, and November 30, 1977, 454 cases of Reye syndrome were reported to the Centers for Disease Control by 43 states. Analysis of data about these cases revealed that Reye syndrome primarily affected white children under age 18 years, with a mean age of 7.7 years and bimodal incidence peaks in infancy and at age 6–7 years, was temporally and geographically associated with influenza B for about 75% of cases, but also occurred sporadically and not in association with influenza B activity. Although Reye syndrome was reported infrequently for non-white children aged one year or older, there was a high incidence in minority infants, and the case-fatality ratio in infants of all races was significantly higher than that of older children. Favorable outcome was associated with prolonged interval between onset of prodromal illness and hospitalization, admission to hospital at a milder stage of illness, and treatment in hospitals with established pediatric training programs.

central nervous system diseases; chicken pox; disease outbreaks; influenza; Reye's syndrome


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Arch Pediatr Adolesc MedHome page
E. L. Chow, J. D. Cherry, R. Harrison, S. V. McDiarmid, and S. Bhuta
Reassessing Reye Syndrome
Arch Pediatr Adolesc Med, December 1, 2003; 157(12): 1241 - 1242.
[Full Text] [PDF]

Home page
 J Child NeurolHome page
K. S. Blisard and L. E. Davis
Neuropathologic Findings in Reye Syndrome
J Child Neurol, January 1, 1991; 6(1): 41 - 44.
[Abstract] [PDF]

Home page
 Arch Pediatr Adolesc MedHome page
F. J. Holtzhauer, R. J. Campbell, L. J. Hall, and T. J. Halpin
Reye's Syndrome: An Epidemiologic Analysis of Mild Disease
Arch Pediatr Adolesc Med, December 1, 1986; 140(12): 1231 - 1236.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.