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American Journal of Epidemiology Vol. 114, No. 2: 253-259
Copyright © 1981 by The Johns Hopkins University School of Hygiene and Public Health

research-article

INDUCTION AND LATENT PERIODS

KENNETH J. ROTHMAN1

1Department of Epidemiology, Harvard School of Public Health 677 Huntington Ave., Boston, MA 02115

Induction and latent periods are distinguishable concepts referring respectively to the period between causal action and disease initiation, and the period between disease initiation and detection. A disease cannot be characterized as having a long or short induction period, except in relation to a specific etiologic component. Inappropriate assumptions, explicit or implicit, about the length of the combined induction and latent period (the "empirical induction period") in an analytic study result in nondifferential misclassification and bias toward the null. Repeated analyses, varying the assumptions about the length of the empirical induction period, can be used to minimize such misclassification, thereby providing estimates for an undiluted measure of effect and the mode of the empirical induction period.

biometry; epidemiologic methods


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