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American Journal of Epidemiology Vol. 114, No. 2: 209-217
Copyright © 1981 by The Johns Hopkins University School of Hygiene and Public Health

research-article

BREAST CANCER INCIDENCE IN WOMEN WITH A HISTORY OF PROGESTERONE DEFICIENCY

LINDA D. COWAN1, LEON GORDIS1, JAMES A. TONASCIA1,2 and GEORGEANNA SEEGAR JONES3

1Department of Epidemiology, School of Hygiene and Public Health, The Johns Hopkins University Baltimore, MD.
2Department of Biostatistics, School of Hygiene and Public Health, The Johns Hopkins University
3Department of Obstetrics and Gynecology, The Johns Hopkins School of Medicine.

In order to investigate the nature of the association of involuntarily delayed first birth and risk of breast cancer, 1083 white women who had been evaluated and treated for infertility from 1945–1965 were followed prospectively through April 1978 to ascertain their breast cancer incidence. These women were categorized as to the cause of infertility into two groups, those with endogenous progesterone deficiency (PD) and those with nonhormonal causes (NH). Women in the PD group had 5.4 times the risk of premenopausal breast cancer compared to women in the NH group. This excess risk could not be explained by differences between the two groups in ages at menarche or menopause, history of oral contraceptive use, history of benign breast dis ease or age at first birth. Women in the PD group also experienced a 10-fold increase in deaths from all malignant neopiasms compared to the NH group. The Incidence of postmenopausal breast cancer did not differ significantly between the two groups.

breast neoplasms; fertility; progesterone


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