American Journal of Epidemiology Vol. 113, No. 6: 675-680
Copyright © 1981 by The Johns Hopkins University School of Hygiene and Public Health
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DIETARY FACTORS IN THE EPIDEMIOLOGY OF CANCER OF THE LARYNX
1Department of Sociology and Social and Preventive Medicine, State University of New York at Buffalo Buffalo, NY 14261.
2Department of Cancer Control and Epidemiology, Roswell Park Memorial Institute Buffalo
3Department of Sociology, State University of New York at Buffalo
4Department of Computer Science, Roswell Park Memorial Institute
5Roswell Park Memorial Institute
Reprint requests to Dr. Graham.
Graham, S. (Dept. of Social and Preventive Medicine, State U. of New York at Buffalo, Buffalo, NY 14261), C. Mettlin, J. Marshall, R. Priore, T. Rzepka and D. Shedd. Dietary factors in the epidemiology of cancer of the larynx. Am J Epidemiol 1981; 113: 675–80.
Interviews were carried out with 374 male patients at Roswell Park Memorial Institute with cancer of the larynx and 381 controls with diseases other than of the digestive or respiratory system and other than neoplasms. As have other investigators, the authors found a high risk associated with smoking as well as a risk associated with alcohol ingestion. In addition, the study found that males ingesting low amounts of vitamin A in their diet had approximately twice the risk of those ingesting large amounts. The same was true for vitamin C. All of these relationships were significant, and risk increased in dose-response fashion with decreases in ingestion of the above-mentioned dietary constituents. When the risks associated with vitamins A and C were examined controlling for smoking and drinking, the risk enhancement associated with low ingestion persisted. The findings on nutrients are consistent with results of studies on animals and tissue cultures. Nevertheless, the sparse epidemiologic replication, the difficulties with the methods, and the complexity of the field demand substantial further inquiry on these relationships.
cancer; diet; larynx; vegetables; vitamin A; vitamin C
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