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American Journal of Epidemiology Vol. 113, No. 1: 50-54
Copyright © 1981 by The Johns Hopkins University School of Hygiene and Public Health

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INTRAFAMILIAL CLUSTER OF HEPATITIS B VIRUS INFECTION: STUDY OF A LARGE FAMILY IN THE UNITED STATES

R. E. SAMPLINER1, B. L. LOEVINGER1, E. TABOR2 and R. J. GERETY2

1Veterans Administration Medical Center and University of Maryland School of Medicine Baltimore, MD 21218. (Send reprint requests to Dr. Sampliner (151) at the VA Medical Center, 3900 Loch Raven Blvd., Baltimore, MD 21218.)
2Hepatitis Branch, Division of Blood and Blood Products, Bureau of Biologies, Federal Drug Administration Bethesda, MD

Sampliner, R. E. (VA Medical Center, Baltimore, MD 21218), B. L. Loevinger, E. Tabor and R. J. Gerety. intrafamllial cluster of hepatitis B virus infection: study of a large family in the United States. Am J Epidemiol 1981;113:50–54.

Seventy-eight persons in an Italian-American family were tested for hepatitis B serologic markers. Fifty-one (65%) had serologic evidence of active or prior hepatitis B infection. Twenty-eight (36%) had evidence of active infection, including twenty-six with hepatitis B surface antigen (HBsAg), and two with antibody to the hepatitis B core antigen only. Severe chronic liver disease was documented in four family members, three of whom had serologic evidence of active hepatitis B infection and the fourth died before the availability of hepatitis B testing. Thirteen of 18 (72%) offspring of six HBsAg positive mothers were HBsAg positive. No epldemlologic explanation of the high prevalence of hepatitis B infection in this family was found, although mother-to-child transmission in years past is a possible explanation.

chronic disease; family; hepatitis; hepatitis B; hepatitis B surface antigen


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