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American Journal of Epidemiology Vol. 113, No. 1: 44-49
Copyright © 1981 by The Johns Hopkins University School of Hygiene and Public Health


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EPIDEMIC KERATOCONJUNCTIVITIS CAUSED BY ADENOVIRUS TYPE 8: EPIDEMIOLOGIC AND LABORATORY ASPECTS OF A LARGE OUTBREAK

LAWRENCE J. D'ANGELO1,, JOHN C. HEERHOLZER2, ROBERT C. HOLMAN3 and J. DAVID SMITH4

1Respiratory and Special Pathogens Branch, Viral Diseases Division, Bureau of Epidemiology, Center for Disease Control PHS, DHEW, Atlanta, GA 30333 (reprint requests to Dr. D'Angelo at this address)
2Respiratory Virology Branch, Virology Division, Bureau of Laboratories, Center for Disease Control PHS, DHEW, Atlanta, GA
3Statistical Services Branch, Viral Diseases Division, Bureau of Epidemiology, Center for Disease Control PHS, DHEW, Atlanta, GA
4Epidemiology Section, Division of Physical Health, Georgia Department of Human Resources 47 Trinity Avenue, Atlanta, GA

1reprint requests to Dr. D'Angelo at this address

D'Angelo, L. J. (Bureau of Epidemiology, CDC, Atlanta, GA 30333), J. C. Hierholzer, R. C. Holman, and J. D. Smith. Epidemic keratoconjunctivitis caused by adenovlrus type 8: epldemlologic and laboratory aspects of a large outbreak. Am J Epidemiol 1981; 113: 44–9.

During late 1977 and early 1978, 192 cases of epidemic keratoconjunctlvttls occurred In a community in central Georgia. In 86 of these cases, the patient had been exposed to a single ophthalmologist's office (physician A) 3–22 days before onset of illness. Patients considered as cases were more likely to have had invasive ophthalmologic procedures than non-cases (p < 0.001), and a linear relationship existed between the number of procedures performed and the attack rate (r = 0.91, p < 0.05). Adenovirus type 8 (AV8) was Identified as the responsible pathogen by culture and/or antibody determination for 20 of these patients. Group-specific AV hexon antigen and type-specific dodecon antigen were Identified in four of seven ophthalmic solutions obtained from physician A's office. The outbreak stopped after proper control techniques were Initiated.

adenovirus infections; disease outbreaks; eye diseases; keratocon-junctivftls; ophthalmic solutions


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