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American Journal of Epidemiology Vol. 112, No. 5: 586-594
Copyright © 1980 by The Johns Hopkins University School of Hygiene and Public Health

other

REPLACEMENT ESTROGENS AND BREAST CANCER1

HERSHEL JICK, ALEXANDER M. WALKER, RICHARD N. WATKINS, DIANE C. D'EWART, JUDITH R. HUNTER, ANNE DANFORD, SUE MADSEN, BARBARA J. DINAN and KENNETH J. ROTHMAN

Reprint requests should be addressed to Dr. Jick, Boston Collaborative Drug Surveillance Program, 400 Totten Pond Rd., Waltham, MA 02154.

The relation between replacement estrogens and breast cancer in menopausal women (age 45–64 years) was evaluated in the Group Health Cooperative of Puget Sound, Washington State, a prepaid health care organization with fully computerized information on outpatient drug use and hospital diagnoses. Little association between current estrogen use and breast cancer was noted in women with a previous hysterectomy (relative risk (RR) = 1.1; 90% confidence interval (Cl), 0.7–1.8). In women with a natural menopause there was a positive association between current estrogen use and breast cancer (RR = 3.4; 90% Cl, 2.1–5.6). This association was strong in naturally menopausal women aged 45–54 years (RR = 10.2) and weaker in the older age group (RR = 1.9).

breast neoplasms; estrogens; risk

1From the Boston Collaborative Drug Surveillance Program, Boston U. Medical Center, Waltham, MA (Dr. Jick, Dr. Walker, Ms. Dinan); Group Health Cooperative of Puget Sound, Seattle, WA (Dr. Watkins, Ms. D'Ewart, Ms. Hunter, Ms. Danford, Ms. Madsen); and the Dept. of Epidemiology, Harvard School of Public Health, Boston, MA (Dr. Rothman).


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