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American Journal of Epidemiology Vol. 112, No. 3: 404-408
Copyright © 1980 by The Johns Hopkins University School of Hygiene and Public Health

other

TWIN PAIRS, SMOKING IN PREGNANCY AND PERINATAL MORTALITY

JACQUELINE FABIA1 and MARGARET DROLETTE2

1 Dept. of Social and Preventive Medicine, Laval U. School of Medicine Quebec, Que. G1K 7P4, Canada
2 Dept. of Biostatistics, Harvard School of Public Health Boston, MA 02115

1Reprint requests to Dr. Fabia at this address.

Twins born in the province of Quebec during the first six months of 1972 were ascertained by reviewing all live births and perinatal death certificates. A total of 852 twins, constituting 426 pairs, were included in the study. Smoking habits of the mother during pregnancy were recorded at the hospital of birth for 88.5% of the pairs. The risk of at least one perinatal death was significantly higher for twin pairs born to smoking mothers. The Mantel-Haenszel test statistic controlling for sex of pairs, parity (0, 1 +), maternal age (<25, 25+ years) and years of schooling was 4.224 (p = 0.04). The standardized risk ratio for smoking versus nonsmoking mothers that a pair will have at least one death was 1.77 (95% confidence limits: 1.03–3.04). As expected, the relative risk of perinatal death associated with smoking appears to be higher for twins than for singletons.

educational status; fetal death; infant mortality; maternal age; parity; smoking; twins


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