American Journal of Epidemiology Vol. 112, No. 3: 388-394
Copyright © 1980 by The Johns Hopkins University School of Hygiene and Public Health
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TOTAL SERUM CHOLESTEROL AND CANCER MORTALITY IN A MIDDLE-AGED MALE POPULATION
1 Equipe de Recherche de Cardiologie INSERM Paris, France
2 Unite 169, INSERM Villejuif, France
Address reprint requests to P. Ducimetiere, Unite 169 INSERM, 16 Bis Avenue P. V. Couturier, 94800 Villejuif, France.
The assessment of total cholesterol level as a risk factor for cancer mortality was studied from data of the Paris Prospective Study of Coronary Heart Disease. A total of 7603 French male government employees aged 43–52 years were followed for an average of 6.6 years. One hundred and thirty-four cancer deaths were registered with a mean survival time of 4.9 ± 2.9 years. At entry in the study, future cancer cases were older than survivors and had a lower corpulence index and lower cholesterol value (212 vs. 223 mg/100 ml, SD = 43 mg/100 ml) than those of survivors. The initial cholesterol level did not differ significantly among cancer sites. The mean cholesterol value increased steadily with survival time (p < 0.02) and reached the mean survivors level in men with survival time longer than seven years. Longitudinal cholesterol measurements obtained among 81% of future cancer cases showed a mean decrease, after an average of 3.0 years, comparable to the one estimated from cross-sectional data. The association between low cholesterol and cancer mortality during a period up to seven years before death is not likely to represent an etiologic link but in all probability reflects the advance of the clinical course of cancer.
cholesterol; coronary disease; mortality; prospective studies
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