American Journal of Epidemiology Vol. 111, No. 1: 23-30
Copyright © 1980 by The Johns Hopkins University School of Hygiene and Public Health
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INFLUENZA A/USSR/77 (H1N1) ON A UNIVERSITY CAMPUS
1Medical Virology Section, Laboratory of Clinical Investigation, National Insitute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, MD 20205
2The University of Maryland Health Clinic College Park, MD 20740
Reprint requests to Dr. Dolin, Infectious Disease Unit, The University of Vermont, Department of Medicine, College of Medicine, Given Medical Building, Burlington, VT 05401
An extensive outbreak of influenza caused by A/USSR/77 (H1N1) virus occurred in February, 1978, at the University of Maryland, College Park, Maryland, and the outbreak was studied by virus isolation, serology, clinical questionnaire and outpatient chart review. Among students who returned questionnaires, clinical attack rates were extraordinarily high (73.2% of those 
23 years of age and 45.7% for those >23 years (p < 0.001)), and rates were higher in students who lived on campus (p < 0.05). Employing the criterion of hemagglutination inhibition titer 
16, 89.8% of those 23 years of age had evidence of infection by March, 1978. Illness was generally mild, and no complications were reported. The extent and rapid spread of this outbreak suggested that only immunoprophyiaxis or rapidly acting control measures such as chemoprophylaxis would be effective in this institutional setting with a highly susceptibie population.
influenza; disease outbreaks
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