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American Journal of Epidemiology Vol. 110, No. 2: 219-226
Copyright © 1979 by The Johns Hopkins University School of Hygiene and Public Health

research-article

ASSESSMENT OF THE ASSOCIATION BETWEEN HABITUAL SALT INTAKE AND HIGH BLOOD PRESSURE: METHODOLOGICAL PROBLEMS1

KIANG LIU, RICHARD COOPER, JEFFREY MCKEEVER, PATRICIA MAKEEVER, ROBERT BYINGTON, IVAN SOLTERO, ROSE STAMLER, FLORA GOSCH, ELIZABETH STEVENS and JEREMIAH STAMLER

Despite the finding in cross-cultural comparisons that habitual sodium intake correlates with levels of blood pressure, similar studies from within population groups have yielded inconsistent results. The data presented in this report indicate that in industrialized societies the high degree of intra-individual variability of sodium intake, compared to much smaller inter-individual differences, may obscure potential biological correlations. A quantitative statistical method is presented to assess and minimize the effect of the large Intra-individual variation in daily urinary sodium excretion.

blood pressure; hypertension; sodium; urine

1 Department of Community Health and Preventive Medicine, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611 (address for reprint requests).


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