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American Journal of Epidemiology Vol. 110, No. 2: 132-140
Copyright © 1979 by The Johns Hopkins University School of Hygiene and Public Health

research-article

FIVE-YEAR ANALYSIS OF ADENOVIRUS 8 ANTIBODY LEVELS IN AN INDUSTRIAL COMMUNITY FOLLOWING AN OUTBREAK OF KERATOCONJUNCTIVITIS

JOHN C. HIERHOLZER and JAMES B. SPRAGUE

Respiratory Virology Branch, Bureau of Laboratories, Center for Disease Control Atlanta, GA 30333
University of Colorado School of Medicine, Department of Ophthalmology Denver

Reprint requests to Dr Hierholzer

Serum hemagglutination-inhibition (HI) antibody titers were monitored for five years with samples from 79 keratoconjunctivitis patients with type 8 adenovirus (AV-8) infection. Geometric mean antibody titers declined from 1:161 at the peak of the epidemic to 1:56 after five years. Computerized analysis of the decline in geometric mean antibody titer indicates that most patients will have a serum HI titer of 1:25 by 10 years after their clinical infection. These residual antibody levels and the consistent failure to document re-infection with AV-8 suggest that recurrent episodes of keratoconjunctivitis are caused by adenovirus serotypes other than type 8.

adenovirus infections; antibodies, viral; eye diseases; hemagglutination-inhibition tests; keratoconjunctivitis


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