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American Journal of Epidemiology Vol. 110, No. 2: 124-131
Copyright © 1979 by The Johns Hopkins University School of Hygiene and Public Health

research-article

DEMONSTRATION OF SPECIFIC ANTIBODIES TO A COXSACKIE-LIKE VIRUS IN PATIENTS OF A HEPATITIS OUTBREAK1

WARREN W SCHULTZ 2 and EMILIO WEISS

Reprint requests to Dr. Weiss

Lynchburg fecal virus (LFV), originally isolated from the stool of an infectious hepatitis patient, was passaged 15 times in WI-38 cells and partially characterized. Its properties are as follows: RNA virus; 27 nm in diameter, picomavirus-like morphology; Inactivated at 56 C for 60 minutes; resistant to treatment with hydrochloric acid (pH 3.0), chloroform (33%), and diethyl ether (20%). Neutralization studies indicated that LFV is antigenically related to coxsacklevirus A-24 but not to prototype hepatitis A virus (HAV). The simultaneous occurrence of infections with LFV and with HAV was indicated by the results of enzyme Immunoassay (EIA) of the sera of patients of the Lynchburg outbreak. Absence of anti-LFV in patient sera was accompanied by an absence of anti-HAV and, conversely, an Increased titer in anti-LFV was accompanied by an Increased titer in anti-HAV. Each antibody type was shown to be elicited independently indicating simultaneous infections with LFV and HAV. The contribution, if any, of LFV to disease in the outbreak remains unknown.

antibodie, viral; coxsacklevlruses; hepatitis A virus; immunoassay

1 From the Department of Microbiology, Naval Medical Research Institute, Bethesda, MD 20014

2 Present address: Department of Chemistry, United States Naval Academy Annapolis, MD


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