American Journal of Epidemiology Vol. 110, No. 2: 105-123
Copyright © 1979 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
GUILLAIN-BARRE SYNDROME FOLLOWING VACCINATION IN THE NATIONAL INFLUENZA IMMUNIZATION PROGRAM, UNITED STATES, 1976–19771
Reprint requests to Dr Schonberger
Because of an increase in the number of reports of Guillain-Barre syndrome (GBS) following A/New Jersey influenza vaccination, the National Influenza Immunization Program was suspended December 16, 1976 and nationwide surveillance for GBS was begun. This surveillance uncovered a total of 1098 patients with onset of GBS from October 1, 1976, to January 31, 1977, from all 50 states, District of Columbia, and Puerto Rico. A total of 532 patients had recently received an A/New Jersey influenza vaccination prior to their onset of GBS (vaccinated cases), and 15 patients received a vaccination after their onset of GBS. Five hundred forty-three patients had not been recently vaccinated with A/New Jersey influenza vaccine and the vaccination status for 8 was unknown. Epidemiologic evidence indicated that many cases of GBS were related to vaccination. When compared to the unvaccinated population, the vaccinated population had a significantly elevated attack rate in every adult age group. The estimated attributable risk of vaccine-related GBS in the adult population was just under one case per 100,000 vaccinations. The period of increased risk was concentrated primarily within the 5-week period after vaccination, although it lasted for approximately 9 or 10 weeks.
Guillain-Barre syndrome; Immunization; Influenza; polyradiculitis; vaccination; vaccine
1 From the Viral Diseases Division, Bureau of Epidemiology, Center for Disease Control, Atlanta, GA 30333.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  N. Agmon-Levin, S. Kivity, M. Szyper-Kravitz, and Y. Shoenfeld Transverse myelitis and vaccines: a multi-analysis Lupus, November 1, 2009; 18(13): 1198 - 1204. [Abstract] [PDF]
|
|
|
|
|
|
H. Orbach and A. Tanay Vaccines as a trigger for myopathies Lupus, November 1, 2009; 18(13): 1213 - 1216. [Abstract] [PDF]
|
|
|
|
 |
|
 L. C. Price Should I have an H1N1 flu vaccination after Guillain-Barre syndrome? BMJ, September 9, 2009; 339(sep09_1): b3577 - b3577. [Full Text]
|
|
|
|
 |
|
 B. A. Slade, L. Leidel, C. Vellozzi, E. J. Woo, W. Hua, A. Sutherland, H. S. Izurieta, R. Ball, N. Miller, M. M. Braun, et al. Postlicensure Safety Surveillance for Quadrivalent Human Papillomavirus Recombinant Vaccine JAMA, August 19, 2009; 302(7): 750 - 757. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. B. Belshe Implications of the Emergence of a Novel H1 Influenza Virus N. Engl. J. Med., June 18, 2009; 360(25): 2667 - 2668. [Full Text] [PDF]
|
|
|
|
 |
|
 J. Stowe, N. Andrews, L. Wise, and E. Miller Investigation of the Temporal Association of Guillain-Barre Syndrome With Influenza Vaccine and Influenzalike Illness Using the United Kingdom General Practice Research Database Am. J. Epidemiol., February 1, 2009; 169(3): 382 - 388. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. F. Vernon and C. Kent Chiropractors and Vaccinations: Ethics is the Real Issue Complementary Health Practice Review, January 1, 2009; 14(1): 36 - 50. [Abstract] [PDF]
|
|
|
|
 |
|
 Committee on Infectious Diseases Prevention of Influenza: Recommendations for Influenza Immunization of Children, 2007-2008 Pediatrics, April 1, 2008; 121(4): e1016 - e1031. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. Daley, L. A. Crane, V. Chandramouli, B. L. Beaty, J. Barrow, N. Allred, S. Berman, and A. Kempe Misperceptions About Influenza Vaccination Among Parents of Healthy Young Children Clinical Pediatrics, June 1, 2007; 46(5): 408 - 417. [Abstract] [PDF]
|
|
|
|
 |
|
 J. D. Grabenstein, P. R. Pittman, J. T. Greenwood, and R. J.M. Engler Immunization to Protect the US Armed Forces: Heritage, Current Practice, and Prospects Epidemiol. Rev., August 1, 2006; 28(1): 3 - 26. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Hughes, J. Charlton, R. Latinovic, and M. C. Gulliford No association between immunization and guillain-barre syndrome in the United kingdom, 1992 to 2000. Arch Intern Med, June 26, 2006; 166(12): 1301 - 1304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. W. McMahon, J. Iskander, P. Haber, S. Chang, E. J. Woo, M. M. Braun, and R. Ball Adverse Events After Inactivated Influenza Vaccination Among Children Less Than 2 Years of Age: Analysis of Reports From the Vaccine Adverse Event Reporting System, 1990-2003 Pediatrics, February 1, 2005; 115(2): 453 - 460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Haber, F. DeStefano, F. J. Angulo, J. Iskander, S. V. Shadomy, E. Weintraub, and R. T. Chen Guillain-Barre Syndrome Following Influenza Vaccination JAMA, November 24, 2004; 292(20): 2478 - 2481. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Madjid, M. Naghavi, S. Litovsky, and S. W. Casscells Influenza and Cardiovascular Disease: A New Opportunity for Prevention and the Need for Further Studies Circulation, December 2, 2003; 108(22): 2730 - 2736. [Full Text] [PDF]
|
|
|
|
|
|
M. B. Rennels, H. C. Meissner, and Committee on Infectious Diseases Technical Report: Reduction of the Influenza Burden in Children Pediatrics, December 1, 2002; 110(6): e80 - e80. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Ahmed, J. A. Singleton, and A. L. Franks Influenza Vaccination for Healthy Young Adults N. Engl. J. Med., November 22, 2001; 345(21): 1543 - 1547. [Full Text] [PDF]
|
|
|
|
|
|
R. B. Couch Prevention and Treatment of Influenza N. Engl. J. Med., December 14, 2000; 343(24): 1778 - 1787. [Full Text] [PDF]
|
|
|
|
 |
|
 U. Seneviratne Guillain-Barre syndrome Postgrad. Med. J., December 1, 2000; 76(902): 774 - 782. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. Van Koningsveld, P. A. Van Doorn, P. I. M. Schmitz, C. W. Ang, and F. G. A. Van der Meche Mild forms of Guillain-Barre syndrome in an epidemiologic survey in the Netherlands Neurology, February 8, 2000; 54(3): 620 - 620. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Freedman and P. B. Stark The Swine Flu Vaccine and Guillain-BarrE Syndrome: A Case Study in Relative Risk and Specific Causation Eval Rev, December 1, 1999; 23(6): 619 - 647. [Abstract] [PDF]
|
|
|
|
|
|
T. Lasky, G. J. Terracciano, L. Magder, C. L. Koski, M. Ballesteros, D. Nash, S. Clark, P. Haber, P. D. Stolley, L. B. Schonberger, et al. The Guillain-Barre Syndrome and the 1992-1993 and 1993-1994 Influenza Vaccines N. Engl. J. Med., December 17, 1998; 339(25): 1797 - 1802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Chen, J. W. Glasser, P. H. Rhodes, R. L. Davis, W. E. Barlow, R. S. Thompson, J. P. Mullooly, S. B. Black, H. R. Shinefield, C. M. Vadheim, et al. Vaccine Safety Datalink Project: A New Tool for Improving Vaccine Safety Monitoring in the United States Pediatrics, June 1, 1997; 99(6): 765 - 773. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Fiebach and W. Beckett Prevention of Respiratory Infections in Adults: Influenza and Pneumococcal Vaccines Arch Intern Med, November 28, 1994; 154(22): 2545 - 2557. [Abstract] [PDF]
|
|
|
|
|
|
P. Gardner and W. Schaffner Immunization of Adults N. Engl. J. Med., April 29, 1993; 328(17): 1252 - 1258. [Full Text]
|
|
|
|
 |
|
 E. C. Alvord Jr Swine Influenza Vaccine and Guillain-Barre Syndrome: Lies, Damn Lies, and... Arch Neurol, October 1, 1986; 43(10): 979 - 979. [Abstract] [PDF]
|
|
|
|
|
|
L. T. Kurland and W. C. Wiederholt Swine Influenza Vaccine and Guillain-Barre Syndrome: Lies, Damn Lies, and...-Reply Arch Neurol, October 1, 1986; 43(10): 979 - 981. [Abstract] [PDF]
|
|
|
|
|
|
E. Beghi, L. T. Kurland, D. W. Mulder, and W. C. Wiederholt Guillain-Barre Syndrome: Clinicoepidemiologic Features and Effect of Influenza Vaccine Arch Neurol, November 1, 1985; 42(11): 1053 - 1057. [Abstract] [PDF]
|
|
|
|
|
|
L. T. Kurland, W. C. Wiederholt, J. W. Kirkpatrick, and H. G. Potter Swine Influenza Vaccine and Guillain-Barre Syndrome: Epidemic or Artifact? Arch Neurol, November 1, 1985; 42(11): 1089 - 1090. [Abstract] [PDF]
|
|
|
|
|
|
C. M. Poser Swine Influenza Vaccination: Truth and Consequences Arch Neurol, November 1, 1985; 42(11): 1090 - 1092. [Abstract] [PDF]
|
|
|
|
 |
|
 U Jahnke, E. Fischer, and E. Alvord Jr Sequence homology between certain viral proteins and proteins related to encephalomyelitis and neuritis Science, July 19, 1985; 229(4710): 282 - 284. [Abstract] [PDF]
|
|
|
|
 |
|
 Prevention and Control of Influenza: Recommendation of the Immunization Practices Advisory Committee Ann Intern Med, August 1, 1984; 101(2): 218 - 222. [Abstract] [PDF]
|
|
|
|
|
|
L. T. Kurland, C. A. Molgaard, E. M. Kurland, W. C. Wiederholt, and J. W. Kirkpatrick Swine Flu Vaccine and Multiple Sclerosis JAMA, May 25, 1984; 251(20): 2672 - 2675. [Abstract] [PDF]
|
|
|
|
|
|
J. E. Kaplan, J. R. Greenspan, M. Bomgaars, N. Wiebenga, R. D. Bart Jr, K. Robbins, R. Wiebe, F. Tabrah, J. Stewart, and L. B. Schonberger Simultaneous Outbreaks of Guillain-Barre Syndrome and Bell's Palsy in Hawaii in 1981 JAMA, November 18, 1983; 250(19): 2635 - 2640. [Abstract] [PDF]
|
|
|
|
|
|
Influenza Vaccines 1983-1984: Recommendation of the Immunization Practices Advisory Committee Ann Intern Med, October 1, 1983; 99(4): 497 - 499. [Abstract] [PDF]
|
|
|
|
|
|
M. A. Riddiough, J. E. Sisk, and J. C. Bell Influenza Vaccination: Cost-effectiveness and Public Policy JAMA, June 17, 1983; 249(23): 3189 - 3195. [Abstract] [PDF]
|
|
|
|
|
|
K. V. Eden Possible Association of Guillain-Barre Syndrome With Thrombolytic Therapy JAMA, April 15, 1983; 249(15): 2020 - 2021. [Abstract] [PDF]
|
|
|
|
|
|
S. B. Thacker, K. Choi, and P. S. Brachman The Surveillance of Infectious Diseases JAMA, March 4, 1983; 249(9): 1181 - 1185. [Abstract] [PDF]
|
|
|
|
|
|
K. W. Bernard, P. W. Smith, F. J. Kader, and M. J. Moran Neuroparalytic Illness and Human Diploid Cell Rabies Vaccine JAMA, December 17, 1982; 248(23): 3136 - 3138. [Abstract] [PDF]
|
|
|
|
|
|
Influenza Vaccines 1982-1983: Recommendation of the Immunization Practices Advisory Committee Ann Intern Med, October 1, 1982; 97(4): 581 - 583. [Abstract] [PDF]
|
|
|
|
|
|
J. E. Kaplan, P. Katona, E. S. Hurwitz, and L. B. Schonberger Guillain-Barre Syndrome in the United States, 1979-1980 and 1980-1981: Lack of an Association With Influenza Vaccination JAMA, August 13, 1982; 248(6): 698 - 700. [Abstract] [PDF]
|
|
|
|
|
|
M. T. OSTERHOLM and J. C. FORFANG Surveillance of Toxic Shock Syndrome in Minnesota: Comments on National Surveillance Ann Intern Med, June 1, 1982; 96(6_Part_2): 887 - 890. [Abstract] [PDF]
|
|
|
|
|
|
S. W. Brostoff and T. M. White Absence of P2 Protein in Swine Flu Vaccines JAMA, January 22, 1982; 247(4): 495 - 495. [Abstract] [PDF]
|
|
|
|
|
|
D. E. Johnson Guillain-Barre Syndrome in the US Army Arch Neurol, January 1, 1982; 39(1): 21 - 24. [Abstract] [PDF]
|
|
|
|
|
|
Influenza Vaccine 1981-1982: Recommendations of the Public Health Service Immunization Practices Advisory Committee Ann Intern Med, October 1, 1981; 95(4): 461 - 463. [Abstract] [PDF]
|
|
|
|
|
|
G. L. Lattimer Legionnaires' Disease Legacies JAMA, November 28, 1980; 244(21): 2416 - 2416. [Abstract] [PDF]
|
|
|
|
|
|
Influenza Vaccine 1980-1981: Recommendation of the Public Health Service Immunization Practices Advisory Committee Ann Intern Med, September 1, 1980; 93(3): 466 - 468. [Abstract] [PDF]
|
|
|
|
|
|
L Gordis and E Gold Privacy, confidentiality, and the use of medical records in research Science, January 11, 1980; 207(4427): 153 - 156. [PDF]
|
|