American Journal of Epidemiology Vol. 109, No. 4: 464-479
Copyright © 1979 by The Johns Hopkins University School of Hygiene and Public Health
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INFLUENZA A AND B VIRUS INFECTION IN INFANTS AND YOUNG CHILDREN DURING THE YEARS 1957–19761
Reprint requests to Dr. Kim, Virology Section, Research Foundation of Children's Hospital National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010.
Influenza A virus activity was demonstrated in infants and young children from metropolitan Washington, DC during each of 19 successive August—July respiratory disease years, and during 17 of these years at least 2% of hospitalized respiratory disease patients yielded an Influenza A or B virus and/or showed an Influenza A or B serum complement-fixing (CF) antibody response. Between October 1957 and July 1976, 14.3% of 860 croup patients and 5.3% of a total of 5655 hospitalized respiratory patients, including croup patients, showed evidence of influenza A or B virus Infection. The mean period of hospitalization with either virus was about 8 days, though serious Infection with influenza A virus was 4.5 times more common than with Influenza B virus. Both influenza viruses were detected more frequently in respiratory disease outpatients than In respiratory disease inpatients. Patients with serious influenza A virus infections were especially likely to have croup (particularly during the H3N2 era), to be seen during December through February, and to be black male infants. During the peak month of a composite of 13 consecutive Influenza A virus outbreaks, Influenza A virus infection was demonstrated In 67.6% of croup patients and in 35.6% of all hospitalized respiratory patients including croup patients. During the peak month of a composite of 6 consecutive Influenza B virus outbreaks, Influenza B virus infection was demonstrated in 36.0% of croup patients and In 10.8% of all hospitalized respiratory disease patients Including croup patients.
croup; influenza; pediatrics; respiratory tract infection; vaccines; virus disease
1From the Virology Section, Research Foundation of Children's Hospital National Medical Center Washington, DC Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, MD George Washington University School of Medicine and Health Sciences Washington, DC
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