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American Journal of Epidemiology Vol. 109, No. 3: 346-351
Copyright © 1979 by The Johns Hopkins University School of Hygiene and Public Health

other

SPERM COUNT DEPRESSION IN PESTICIDE APPLICATORS EXPOSED TO DIBROMOCHLOROPROPANE

R. I. GLASS1,1, R N. LYNESS2, D. C. MENGLE2, K. E. POWELL1 and E. KAHN2

1 Chronic Diseases Division, Bureau of Epidemiology, Center for Disease Control Atlanta, GA 30333
2 Community Studies on Pesticides, California Department of Health Berkeley, CA 94704
3 Epidemiological Studies Laboratory, California Department of Health Berkeley, CA 94704

1Reprint requests to Dr. Roger Glass at this address

Male pesticide applicators who worked with the nematocide dibromochloropropane (DBCP) were examined to determine the possible testicular toxicity from this exposure. Infertility and azoospermia which were first noted among factory workers exposed to DBCP were not observed among the applicators. Sperm count depression, however, was associated with the duration of exposure in the current year but not with exposure in past years. The extent of exposure to DBCP in the current year was also associated with an elevation of serum follicle stimulating hormone (FSH) but not of lutelnizing hormone (LH). Sperm count depression was limited to applicators involved in irrigation setup work and In the calibration of equipment. These results suggest that the testicular toxicity of DBCP for men may occur In a shorter period than was previously reported, that the effect may be reversible in men with mild sperm count depression, and that public health measures might be directed at controlling specific application techniques.

antinematodal agents; FSH; hydrocarbons; halogenated; LH; occupational diseases; oligospermia; propane; sterility


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