American Journal of Epidemiology Vol. 107, No. 6: 529-537
Copyright © 1978 by The Johns Hopkins University School of Hygiene and Public Health
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EPIDEMIC KEPONE POISONING IN CHEMICAL WORKERS
1 Cancer and Birth Defects Division, Bureau of Epidemiology, Center for Disease Control Atlanta, GA 30333
2 Formerly, Field Services Division, Bureau of Epidemiology, CDC, located in the Virginia Health Department. Presently, Infectious Diseases and Hospital Epidemiology, Medical College of Virginia Hospital Richmond, Va
3 Virginia State Department of Health Richmond, VA
4 Toxicology Branch, Clinical Chemistry Division, Bureau of Laboratories CDC, Atlanta
5 Epidemiology Branch, Health Effects Research Laboratory. Environmental Protection Agency Research Triangle Park, NC
6 National Institute for Occupational Safety and Health Region III, Philadelphia, PA
7 Toxicology Branch, Clinical Chemistry Division, Bureau of Laboratories CDC, Atlanta
1 Address for reprint requests.
From March 1974 through July 1975, 76 (57%) of 133 persons who had worked at a pesticide plant that produced Kepone, a chlorinated hydrocarbon insecticide, contracted a previously unrecognized clinical Illness characterized by nervousness, tremor, weight loss, opsoclonus, pleuritic and Joint pain, and oligospermia. Illness Incidence rates for production-workers (64%) were significantly higher than for nonproduction personnel (16%). The mean blood Kepone level for workers with Illness was 2.53 ppm and for those without disease 0.60 ppm (p<0.001). Blood Kepone levels In current workers (mean, 3.12 ppm) were higher than those In former employees (1.22 ppm). Blood Kepone levels for workers In nearby businesses and for residents of a community within 1.6 km of the plant ranged from undetectable to 32.5 ppb. Illness attributable to Kepone was found In two wives of Kepone workers; there was no apparent association between frequency of symptoms and proximity to the plant In the survey of the community population.
epidemics; insecticides, organochlorine; Kepone; occupational diseases; pesticides; poisoning
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