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American Journal of Epidemiology Vol. 107, No. 4: 336-343
Copyright © 1978 by The Johns Hopkins University School of Hygiene and Public Health

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ANTIGENIC RELATEDNESS OF 17 STRAINS OF HUMAN CYTOMEGALOVIRUS1

SHARON L. ZABLOTNEY 2, BERTTINA B. WENTWORTH 3 and E. R. ALEXANDER4

4 Reprint requests to Dr. Alexander, Department of Epidemiology, School of Public Health, University of Washington Seattle, WA 98195.

A 10 minute kinetic neutralization test was used to assess antigenic relatedness among 17 strains of human cytomegalovirus. Hyperimmune guinea pig sera exhibited extensive cross-reactivity. However, the data did suggest that there may be four antigenic groups represented in this collection of CMV strains. Available epidemiologic data for these strains do not provide any discernible basis for this grouping.

antigens; cytomegaloviruses; neutralization tests

1From the Department of Pathobiology and Department of Epidemiology, University of Washington.

2 Present address: School of Allied Health, Clinical Laboratory Sciences, Ferris State College, Big Rapids, MI.

3 Present address: Bureau of Disease Control and Laboratory Services, Michigan Department of Public Health, Lansing, MI.


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