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American Journal of Epidemiology Vol. 106, No. 6: 470-475
Copyright © 1977 by The Johns Hopkins University School of Hygiene and Public Health

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LATITUDE, MIGRATION, AND THE PREVALENCE OF MULTIPLE SCLEROSIS

BARBARA R VISSCHER, ROGER DETELS, ANNE H COULSON, ROBERTA M MALMGREN and JAN P. DUDLEY

Division of Epidemiology, School of Public Health, University of California Los Angeles, CA 90024

Reprint requests to Dr. Visscher.

Visscher, B. R. (School of Public Health, U. of California, Los Angeles, CA 90024), R. Detels, A. H. Coulson, R. M. Malmgren and J. P. Dudley. Latitude, migration, and the prevalence of multiple sclerosis. Am J Epidemiol 106:470–475, 1977.

Prevalence of multiple sclerosis (MS) was determined in three groups of Caucasians in King and Pierce Counties (Washington) and in Los Angeles County (California): natives (bom in study state), migrants from high-risk states (North), and migrants from low-risk states (South). A diagnosis of definite or probable MS (excluding migrants with onset before migration) was established in 1816 of the persons found. The prevalences in Los Angeles County natives and in migrants from the South to either Los Angeles County or King-Pierce Counties were relatively low, while prevalences in King-Pierce Counties among natives and migrants from the North were high. The prevalence in migrants from the North to Los Angeles was intermediate. The results suggest that some degree of protection is provided to migrants by residence In low-prevalence areas, either early or later in life.

genetics; population; multiple sclerosis; transients and migrants


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