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American Journal of Epidemiology Vol. 106, No. 6: 462-469
Copyright © 1977 by The Johns Hopkins University School of Hygiene and Public Health

other

THE INCIDENCE OF CERVICAL CANCER AND DURATION OF ORAL CONTRACEPTIVE USE

ERIC PERITZ, SAVITRI RAMCHARAN, JESS FRANK, WILLARD L. BROWN, SYLVIA HUANG and ROSE RAY

From the Kaiser-Permanente Contraceptive Drug Study, Walnut Creek, California. This study is supported by contract No NO1-HD-3-2710 with the National Institute of Child Health and Human Development, Department of Health, Education, and Welfare.

Reprint requests to Dr. Ramcharan, Contraceptive Drug Study, Kaiser-Permanente Medical Center, 1515 Newell Ave., Walnut Creek, CA 94596

Perttz, E., S. Ramcharan (Kaiser-Permanente Medical Center, Walnut Creek, CA 94596), J. Frank, W. L. Brown, S. Huang and R. Ray. The incidence of cervical cancer and duration of oral contraceptive use. Am J Epidemiol 106:462–469, 1977.

In a prospective study carried out on a cohort of 17,942 women belonging to the Kaiser Foundation Health Plan and living in suburban communities of the San Francisco Bay Area, a positive association was found between the incidence of cervical carcinoma and total duration of oral contraceptive use. The association was established while controlling for the effects of age, education, marital status, number of Pap smears before entry, religion, smoking, and selected infections. The association persists when incident cases of dysplasia are added to those of carcinoma. A further study, in which covariates relating to sexual behavior will also be taken into account, is in progress.

cervical cancer; dysplasia; oral contraceptives


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