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American Journal of Epidemiology Vol. 106, No. 2: 130-138
Copyright © 1977 by The Johns Hopkins University School of Hygiene and Public Health

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THE FAMILIES OF PATIENTS WITH ACUTE RHEUMATIC FEVER OR GLOMERULONEPHRITIS IN TRINIDAD1

ELIZABETH V. POTTER2, MAURI SVARTMAN, THEO POON-KING and DAVID P. EARLE

1Streptococcal Disease Unit, San Fernando General Hospital, Trinidad & Tobago; and Section of Nephrology and Hypertension, Department of Medicine, Northwestern University-McGaw Medical Center Chicago, IL

2Reprint requests to Dr. Potter, 303 East Chicago Avenue, Chicago, IL. 60611.

Potter, E. V. (303 E. Chicago Ave., Chicago, IL 60611), M. Svartman, T. Poon-KIng and D. P. Earle. The families of patients with acute rheumatic fever or glomerulonephrltis in Trinidad. Am J Epidemiol 106:130–138, 1977.

The families of 21 patients with acute rheumatic fever (ARF) and 44 patients with acute glomerulonephritis (AGN) in Trinidad were examined in their homes. The ARF and AGN families were equally large and crowded and they lived in the same largely rural areas. However, only 22% of the ARF family members had skin infections in contrast to 61% of the AGN family members. Sixty-eight per cent of skin infections in ARF families and 69% of skin infections in AGN families yielded group A streptococci. Throat cultures were positive in 19% of ARF family members and 25% of AGN family members. Thirty-two per cent of 51 group A strains isolated from ARF family members (29 from throat, 22 from skin) were M11 or "M41" strains which were associated with ARF during the study, while only 8% were M1, T4 (MNT or 60) or M55 strains which were associated with AGN. In contrast, 49% of 171 group A strains isolated from AGN family members (64 from throat, 107 from skin) were M1, T4 (MNT or 60) or M55 while only 10% were M11 or "M41." Serum antibody titers were similar in both groups: antistreptolysin-0 titers were not markedly increased in either while anti-hyaluronidase and/or antideoxyribonuclease-B titers were increased in both. Evidence of subclinical AGN was found equally often in both groups: 6% of each had abnormal urine and 4% of each had decreased serum complement while 2% of the ARF and 3% of the AGN family members had both abnormal urine and decreased serum complement.

family; glomerulonephritis; nephritis; rheumatic fever


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