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American Journal of Epidemiology Vol. 105, No. 1: 75-86
Copyright © 1977 by The Johns Hopkins University School of Hygiene and Public Health

other

CHARACTERISTICS OF SMOKERS, NON-SMOKERS AND EX-SMOKERS AMONG 10, 000 ADULT MALES IN ISRAEL

II. PHYSIOLOGIC, BIOCHEMICAL AND GENETIC CHARACTERISTICS

URI GOLDBOURT1 3 and JACK H. MEDALIE2

1Department of Research and Sports Medicine, Wingate Institute for Physical Education and Sport Israel
2Department of Family Medicine, Case Western Reserve University, 2119 Abington Road, Cleveland, OH 44106. Previously with the Israeli Ischemic Heart Disease Study and the Department of Family Medicine, Sackler School of Medicine, Tel Aviv University Tel Aviv, Israel

Physiologic, biochemical and genetic characteristics of current smokers, non-smokers and ex-smokers were compared among a study population of almost 10,000 working men aged 40–65 years in Israel. Many significant differences were found, although most differences were small. Current and ex-smokers were slightly taller than non-smokers, and height was correlated to amount smoked. Current smokers had lower weights (absolute and adjusted), skinfolds, systolic and diastolic blood pressures, and uric acid levels, but had higher pulse rates and higher concentrations of total and ß-cholesterol, hemoglobin and hematocrit. They showed, however, lower {alpha}-cholesterol (absolute and relative) concentrations. All the above differences were dose-response-related but discriminant analysis incorporating socio-demographic and behavioral correlates revealed only a moderate degree of combined discrimination. The conclusion is that, while cigarette smokers differ from non-smokers in many ways, the overall difference is unimpressive. This explains why, in prospective analysis, increased mortality and morbidity among smokers could not be attributed to confounding variables. Ex-smokers resembled current smokers in height and cholesterol but were closer to nonsmoker's levels of weight, skinfolds, blood pressure, uric acid and {alpha}-cholesterol. Ex-smokers also had intermediate levels of hemoglobin and hematocrit. Cigar and pipe smokers differed from non-smokers only in their elevated levels of cholesterol and uric acid. There was no variation by smoking habits among blood groups of seven types. It is concluded that an overall similarity exists between different smoking groups mainly in terms of coronary risk factors, and that therefore, constitutional differences do not account for the increased mortality and morbidity among smokers.

biochemistry; blood pressure; cholesterol; genetics, human; physiology; smoking; uric acid

3Supported by P. L. 480 counterpart funds, Research Agreement No. 375106.


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