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American Journal of Epidemiology Vol. 103, No. 6: 560-564
Copyright © 1976 by The Johns Hopkins University School of Hygiene and Public Health

research-article

PLACE AND TIME ASPECTS OF THE OCCURRENCE OF DOWN'S SYNDROME1

KENNETH J ROTHMAN2 and JACQUELINE J. FABIA

2Reprint requests to Dr. Rothman, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115

Prevalence rates at birth for Down's syndrome were compared for Massachusetts communities of different population densities. Overall, there was a small positive association between the rate of Down's syndrome and population density, entirely attributable to a strong association for the children of older mothers. An analysis for space and time clustering of births of 2469 children born in Massachusetts with Down's syndrome revealed no aggregation of cases, except for a slight seasonal peak in the summer.

Down's syndrome; maternal age; population density

1From the Department of Epidemiology, Harvard School of Public Health, Boston, and the Department of Social and Preventive Medicine, Laval University, Quebec.


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