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American Journal of Epidemiology Vol. 103, No. 1: 67-74
Copyright © 1976 by The Johns Hopkins University School of Hygiene and Public Health

research-article

SUBACUTE SCLEROSING PANENCEPHALITIS: AN EPIDEMIOLOGIC STUDY IN ISRAEL

DOV SOFFER1, LOTTE RANNON2, MILTON ALTER3, ESTHER KAHANA4 and SHAUL FELDMAN1

1Uri Leibowitz Neuroepidemiology Unit, Department of Neurology, Hadassah University Hospital Jerusalem, Israel
2Central Virus Laboratory, Ministry of Health Tel Aviv, Jaffa, Israel
3Neuroepidemiology and Genetics Laboratory, Department of Neurology, University of Minnesota Minneapolis, MN 55417
4Barzilai Hospital Ashkelon, Israel

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Subacute sclerosing panencephalitis (SSPE), a disease related to measles (rubeola) infection, was more common in Arabs and Sephardi Jews than in Ashkenazi Jews in Israel. There were no familial aggregates and it is unlikely that genetic differences account for this selectivity. Among several non-genetic factors which might explain the selectivity, family size emerged as a possible risk factor. Family size has not previously been suspected as influencing the risk of SSPE. Preponderance of SSPE in rural areas and among the poor would also be compatible with this idea as family size tends to be larger in rural and lower socioeconomic groups. In large families, there may be a greater change that older siblings will transmit measles to very young siblings. In small families, measles may be acquired from peers at about school age when risk of SSPE may be lower.

age factors; ethnic groups; family characteristics; measles; socioeconomic factors; subacute sclerosing panencephalitis


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