American Journal of Epidemiology Vol. 102, No. 6: 514-525
Copyright © 1975 by The Johns Hopkins University School of Hygiene and Public Health
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EPIDEMIOLOGIC STUDIES OF CORONARY HEART DISEASE AND STROKE IN JAPANESE MEN LIVING IN JAPAN, HAWAII AND CALIFORNIA: PREVALENCE OF CORONARY AND HYPERTENSIVE HEART DISEASE AND ASSOCIATED RISK FACTORS1
2Program in Epidemiology, School of Public Health, University of California at Berkeley Honolulu, Hawaii
3Honolulu Heart Study Honolulu, Hawaii
4Department of Epidemiology and Statistics, Atomic Bomb Casualty Commission, Hiroshima Hiroshima Branch, Japanese National Institute of Health Hiroshima, Japan
5Formerly Department of Medicine, Atomic Bomb Casualty Commission Hiroshima, Japan
Marmot. M. G. (School of Public Health. U. of California, Berkeley. CA 94720). S. L. Syme, A. Kagan, H. Kato. J. B. Cohen and J. Belsky. Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California: Prevalence of coronary and hypertensive heart disease and associated risk factors.Am J Epidemiol102:514–525. 1975.
A study of coronary heart disease (CHD) among Japanese migrants compared with Japaneseliving in Japan provided the opportunity to study factors possibly responsible for the high rates of CHD in America as compared with Japan. Comparable methods were employed in examining 11, 900 men of Japanese ancestry aged 45–69 living in Japan, Hawaii and California. The age-adjusted prevalence rates for definite CHD as determined by ECG were: Japan 5.3, Hawaii 5.2 and California 10.8/1000. For definite plus possible CHD therates were 25.4, 34.7 and 44.6. The prevalence of angina pectoris and pain of possible myocardial infarction, determined by questionnaire, showed a similar gradient. Elevated serum cholesterol showed a Japan-Hawaii-California gradient, but the prevalence of hypertension in Japan was intermediate between the prevalence in Hawaii and the higher prevalence in California. The three geographic locations were compared as to prevalence of CHD at comparable levels of blood pressure and cholesterol. At each blood pressure level and at each cholesterol level, the greater prevalence of CHD in California persisted. These facts, plus the near universality of smoking in Japan, suggest that conventional risk factors only partly explain the observed gradient in CHD.
blood pressure; coronary heart disease; epidemiology; glucose; lipids; migrants; mortality
1From the Epidemiology Program, School of Public Health, University of California at Berkeley; Honolulu Heart Study, Honolulu, Hawaii; and the Atomic Bomb Casualty Commission, Hiroshima and Nagasaki, Japan.
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