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American Journal of Epidemiology Vol. 102, No. 5: 414-421
Copyright © 1975 by The Johns Hopkins University School of Hygiene and Public Health

other

ORAL POLIO VACCINATION OF CHILDREN IN THE TROPICS

II. ANTIBODY RESPONSE IN RELATION TO VACCINE VIRUS INFECTION1

T. JACOB JOHN 2

John, T. J. (Dept of Pediatrics, Univ. of Arizona Med. Ctr., Tucson, AZ 85724). Oral polio vaccination of children in the tropics. II. Antibody response in relation to vaccinevirus infection.Am J Epidemiol 102:414–421,1975.

Poliovirus antibody response rates following the administration of trivalent oral polio vaccine (OPV) have been poor in several developing countries. In an attempt to determine if poor seroresponse is due to poor rates of vaccine virus "take" or due to poor serum antibody response to intestinal virus infection, both vaccine virus take and serum antibody response were determined in a group of children given two doses of OPV. In the large majority of seronegative children there was good correlation between the absence or presence of vaccine virus excretion and negative or positive seroconversion, thusshowing that the poor seroconversion rates were mainly due to poor rates of vaccine virustake. However, as in several studies from developed countries showing good seroconversionrates, a few instances of antibody response in the absence of detectable virus excretion and fewer instances of virus excretion without detectable antibody response were also found.

intestinal virus infection; poliovirus vaccine, oral; seroconversion, serology; tropical medicine

1From the Enterovirus Laboratory, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.

2Present address: Department of Pediatrics, University of Arizona Medical Center, Tucson, Arizona 85724.


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Control of influenza and poliomyelitis with killed virus vaccines
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[Abstract] [PDF]


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