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American Journal of Epidemiology Vol. 102, No. 2: 170-178
Copyright © 1975 by The Johns Hopkins University School of Hygiene and Public Health

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TWINNING RATES AMONG WOMEN AT THE END OF THEIR REPRODUCTIVE SPAN AND THEIR RELATION TO AGE AT MENOPAUSE

GRACE WYSHAK1

1From the Yale University School of Medicine, Department of Epidemiology and Public Health

Wyshak, G. (Yale U. School of Medicine, New Haven, CT 06510). Twinning rates among women at the end of their reproductive span and their relation to age at menopause. Am J Epidemiol 102:170–178, 1975.—A review of studies on twinning has shown that dizygotic (DZ) twinning rates among women from general populations characteristically peak at ages 35–39, then decline sharply. Analysis of genealogical data from the Archives of the Mormon Church indicates that women who are dizygous twins themselves or the sibs of dizygous twins have a higher twinning rate among their offspring than do women from the general population. The dizygotic twinning rates of women who are twins or the sibs of twins classified by maternal age also peak at ages 35–39 but remain high at ages 40–44, then decline. It is well known that Negro women have highDZ twinning rates; a less well known finding is that the DZ twinning rates of Negro womenalso remain high after age 39. It has been suggested that high DZ twinning rates at latermaternal ages may be related to a delayed age at menopause. However, published reports onage at natural menopause and analysis of our data from contemporary white US women indicate the contrary. Women who have borne unlike-sexed (DZ) twins and Negro women have a lower age at natural menopause then do white women from general populations, and a lower age in comparison with women who have borne like-sexed twins.

birth order; birth rate, twinning; genetics, human; maternal age; menopause; race; twins


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