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American Journal of Epidemiology Vol. 102, No. 1: 47-54
Copyright © 1975 by The Johns Hopkins University School of Hygiene and Public Health

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EPIDEMIOLOGIC CHARACTERISTICS OF PATIENTS WITH PROSTATIC NEOPLASMS1

HAROUTUNE K. ARMENIAN 2, ABRAHAM M. LILIENFELD, EARL L. DIAMOND and IRWIN D. J. BROSS

Reprint requests to: Dr. Abraham M. Lilienfeld, Department of Epidemiology, Johns Hopkins University, School of Hygiene and Public Health, 615 N. Wolfe Street, Baltimore, MD 21205.

Armenian. H. K., A. M. Lilienfeld (Johns Hopkins U. School of Hygiene and Public Health. 615 N. Wolfe St. Baltimore, MD 21205), E. L. Diamond and I. D. J. Bross. Epidemiologic characteristics of patients with prostatic neoplasms. Am J Epidemiol 102:47–54, 1975.—A case-control study was conducted between 1957 and 1965 on 128 patients with benign prostatic hyperplasia (BPH), 256 age-matched controls, 290 prostate cancer patients and 290 age-matched controls for the prostate cancer patients, all of whom had completed the Roswell Park Memorial Institute epidemiology questionnaire and wereinterviewed on admission to the Institute. Compared to the control groups a higher proportion of both case groups were Protestants and residents of smaller towns. The major finding in this case-control study was a significantly higher risk for prostate cancer in fertile males compared to both married and non-married, but infertile males. This finding wasconfirmed when fertility was used as a variable for the classification of study groups inan earlier prospective study reporting the follow-up of patients with BPH and non-neo-plastic controls. In this study, patients with children were found to have a relative risk of 2.69 for prostate cancer compared to the married patients with no children. Fertility may be a manifestation of constitutional-hormonal factors that increase the risk of prostate cancer.

fertility; hormones; prostatic hyperplasia; prostatic neoplasms

1From the Department of Epidemiology, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, MD, and the Department of Biostatistics, Roswell Park Memorial Institute Buffalo, NY (Dr. Bross).

2Present address: Department of Epidemiology and Biostatistics, School of Public Health, American University of Beirut, Beirut, Lebanon.


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