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American Journal of Epidemiology Vol. 101, No. 6: 527-531
Copyright © 1975 by The Johns Hopkins University School of Hygiene and Public Health

research-article

MEASLES (RUBEOLA) SUSCEPTIBILITY AMONG ELEMENTARY SCHOOLCHILDREN1

JANAL M. KALIS, PAUL G. QUIE and HENRY H. BALFOUR, Jr.2

2 Reprint requests to Dr. Balfour, Box 437 Mayo, University of Minnesota Health Sciences Center, Minneapolis, Minnesota 55455.

Measles (rubeola) immunity among 479 elementary schoolchildren from suburban Minneapolis was serologically surveyed in December 1971. Of the 479 children, 25 (5.2%) had hemagglu tination-inhibition (HI) titers <2. These children were considered susceptible to measles. For the 233 immunized children with no measles history, 13 (5.6%) had rubeola HI titers <2 while 5 (5.1%) of the 98 youngsters with a history of clinical measles had rubeola HI titers <2. Of the 454 immune children, 73 (16%) had measles HI titers between 2 and 8. These findings confirm durable immunity and a low rate of vaccine failure following live attenuated measles vaccination but demonstrate the importance of testing sera beginning at a dilution of 2 in order to detect children with low antibody levels. This survey also suggests that maternal antibody interferes with the active immune response in youngsters immunized when <1 year of age because this group of children had significantly lower geometric mean titers and significantly more susceptibles than the children immunized when ≥2 years.

hemagglutination-inhibition; measles; rubeola; vaccination

1 From the Departments of Laboratory Medicine, Pathology, Surgery and Pediatrics, University of Minesota Medical School, and the Division of Medical Laboratories, Minnesota Department of Health.


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