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American Journal of Epidemiology Vol. 101, No. 6: 517-526
Copyright © 1975 by The Johns Hopkins University School of Hygiene and Public Health

research-article

REYE'S SYNDROME: EPIDEMIOLOGIC AND VIRAL STUDIES, 1963–19741

CALVIN LINNEMANN, Jr.2, LINDA SHEA, JOHN C. PARTIN, WILLIAM K. SCHUBERT and GILBERT M. SCHIFF

2 Reprint requests to Dr. Linnemann, College of Medicine, U. of Cincinnati, Cincinnati, Ohio 45267.

Fifty-eight children with Reye's syndrome (RS) confirmed by liver biopsy were treated at the University of Cincinnati between 1963 and 1974. Cases were clustered in the winter and spring with the peak in February and March. These coincided with the occurrence of influenza and, numerically, were associated more closely with influenza B than with influenza A. Six of the 58 cases were associated with chickenpox. Twenty-six children with RS were seen from 1963 to 1971, before the beginning of a systematic epidemiologic and virologic study. Viral infection was documented in either the patient or a contact in only 19% of those studied. Between 1971 and 1973, after the study was initiated, 16 cases of RS were diagnosed and viral infection was confirmed in 56% of these. In 1974, an epidemic of RS occurred during an influenza B epidemic and viral infection was found in either the patient or a contact in 81% of 16 cases. This study demonstrates that an association with viral infection can be proven in the majority of cases of RS when an intensive investigation is undertaken. During this study no significant environmental toxic exposures could be identified. Most children had taken aspirin and other medications, and seven children had a history of excessive aspirin ingestion.

chickenpox; disease outbreaks; fatty liver; influenza viruses; Reye's syndrome; viruses

1 From the Departments of Medicine and Pediatrics, University of Cincinnati College of Medicine, and the Children's Hospital Research Foundation, Cincinnati, Ohio


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